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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-RapaLink-1
RapaLink-1

Chemical Structure : RapaLink-1

CAS No.: 1887095-82-0

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RapaLink-1 (RapaLink 1, RapaLink1)

货号: PC-60418Not For Human Use, Lab Use Only.

RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.

规格 价格 库存 数量
1 mg ￥2580 In stock
2 mg ￥3980 In stock
5 mg ￥6580 In stock
10 mg Get quote
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.
RapaLink-1 blocks mTOR signaling of the F2108L mTOR and M2327I mTOR drug resistant mutants.
RapaLink-1 is more potent mTOR inhibitor than rapamycin.

物理化学性质&存储条件

分子量 1784.165
分子式 C91H138N12O24
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

40-O-(2-((1-(32-(4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-27-oxo-3,6,9,12,15,18,21,24-octaoxa-28-azadotriacontyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)-rapamycin

参考文献

1. Rodrik-Outmezguine VS, et al. Nature. 2016 Jun 9;534(7606):272-6.

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