RX-207 (RX207)

Chemical Structure : RX-207

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货号: PC-20580Not For Human Use, Lab Use Only.

RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.

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生物&药学活性

RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
RX-207 (50 mg/kg) inhibited neutrophil migration into the peritoneal cavity by 37% in a mouse model of thioglycollate-induced peritonitis.
Intramuscular (i.m.) injection of RX-207 (1 mg/kg, 0.1 mL) inhibited carrageenan-induced paw edema in mice (32%).
RX-207 (30 uM) inhibited binding of the pro-inflammatory chemokine, MCP-3, to heparin, a highly sulfated form of the cell surface GAG, heparan sulfate.
RX-207 (30 μM) inhibited binding of the pro-inflammatory chemokine, IP-10, to the extracellular matrix GAG, chondroitin sulfate.

物理化学性质&存储条件

分子量	382.51
分子式	C22H30N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-isopropylpiperidin-4-yl)-12-oxo-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline-3-carboxamide

参考文献

1. Stefan Juhas, et al. Inflammation. 2018 Feb;41(1):307-314.

RX-207 (RX207)

生物&药学活性

物理化学性质&存储条件

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RX-207 (RX207)

生物&药学活性

物理化学性质&存储条件

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