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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Selectin-RX-105
RX-105

Chemical Structure : RX-105

CAS No.: 449767-89-9

RX-105 (RX105)

货号: PC-20581Not For Human Use, Lab Use Only.

RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).
    RX-105 inhibited binding of L-selectin to heparin with IC50 of 15 uM, inhibited selectin, chemokine and cytokine binding to GAGs.
    RX-105 (5-50 mg/kg) inhibited paw edema dose dependently in paw edema animal model.

    物理化学性质&存储条件

    分子量 582.80
    分子式 C29H34N4O3S3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3-(benzo[d]thiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-4-(N-butyl-N-ethylsulfamoyl)benzamide

    参考文献

    1. Nicholas Harris, et al. Biochim Biophys Acta. 2014 Jan;1840(1):245-54.

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