RUVBL1/RUVBL2 inhibitor Compound B

Chemical Structure : RUVBL1/RUVBL2 inhibitor Compound B

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货号: PC-25731Not For Human Use, Lab Use Only.

RUVBL1/RUVBL2 inhibitor Compound B is a potent, specific and orally bioavailable RUVBL1/2 ATPase (pontin/TIP49 and reptin/TIP48) inhibitor with IC50 of 59 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

RUVBL1/RUVBL2 inhibitor Compound B is a potent, specific and orally bioavailable RUVBL1/2 ATPase (pontin/TIP49 and reptin/TIP48) inhibitor with IC50 of 59 nM.
Compound B (100 nM) depleted PIKK-family members DNA-PKCS (PRKDC), ATM, and ATR in H2009 cells, all of which require RUVBL1/2 ATPase activity for stability.
Compound B treatment reduced the levels of ATM, ATR, and DNA-PKCS in mice bearing subcutaneous NSCLC xenografts.
Compound B kills NSCLC due to the inhibition of RUVBL1/2.
Compound B inhibits PAQosome maturation.
Compound B radiosensitizes NSCLC, but not normal cells.

物理化学性质&存储条件

分子量	536.03
分子式	C28H30ClN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S)-3-(5-(5-chloro-2-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)cyclohexane-1-carboxamide

参考文献

1. Yenerall P, et al. Cell Chem Biol. 2020 Jan 16;27(1):105-121.e14.