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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-RTx-152
RTx-152

Chemical Structure : RTx-152

CAS No.: 3035072-48-8

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RTx-152 (RTx152)

货号: PC-24443Not For Human Use, Lab Use Only.

RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells.
RTx-152 also exhibits synergistic activity with Olaparib in BRCA2-null cells.

物理化学性质&存储条件

分子量 479.35
分子式 C20H16F7N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbamic acid, N-(4-fluorophenyl)-N-methyl-, 2-(3-methyl-2-oxo-1-imidazolidinyl)-4,6-bis(trifluoromethyl)phenyl ester

参考文献

1. Fried W, et al. Nat Commun. 2024 Apr 5;15(1):2862.

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