RTY-406 (RTY406)

Chemical Structure : RTY-406

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货号: PC-28075Not For Human Use, Lab Use Only.

RTY-406 is a dual-acting ABCB4/BSEP (ATP-binding cassette subfamily B member 4 / bile salt export pump) positive functional modulator (PFM), increases ABCB4 and BSEP protein levels and functional output, thereby increasing biliary phospholipid secretion and bile acid efflux.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

RTY-406 is a dual-acting ABCB4/BSEP (ATP-binding cassette subfamily B member 4 / bile salt export pump) positive functional modulator (PFM), increases ABCB4 and BSEP protein levels and functional output, thereby increasing biliary phospholipid secretion and bile acid efflux.
RTY-406 increased biliary phospholipids and reduced markers of cholestasis, cholangitis, ductular reaction, and fibrosis in mouse model of PSC-like cholestatic disease.
RTY-406 produced dose-dependent reductions in GGT (gamma-glutamyl transferase) and serum cholesterol, along with changes consistent with increased ABCB4 and BSEP activity in healthy cynomolgus monkeys.

物理化学性质&存储条件

分子量	384.82
分子式	C19H17ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Pyrano[3,2-c]pyridine-7-carboxamide, 4-[[(6-chloro-1-methyl-1H-indol-2-yl)carbonyl]amino]-3,4-dihydro-, (4R)-

参考文献

1. Patent WO2025129023 A1 2025-06-19.

RTY-406 (RTY406)

生物&药学活性

物理化学性质&存储条件

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RTY-406 (RTY406)

生物&药学活性

物理化学性质&存储条件

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