RTS-V5 | CAS 2285346-31-6 Probechem Biochemicals

Chemical Structure : RTS-V5

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RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5)

货号: PC-35757Not For Human Use, Lab Use Only.

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3.

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生物&药学活性

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3.
RTS-V5 demonstrates cytotoxicity against leukemia and multiple myeloma cell lines as well as therapy-refractory primary patient-derived leukemia cells.

物理化学性质&存储条件

分子量	525.606
分子式	C27H35N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-((S)-1-(((S)-1-(Benzylamino)-1-oxopropan-2-yl)amino)-4-(neopentylamino)-1,4- dioxobutan-2-yl)-N4 -hydroxyterephthalamide

参考文献

1. Bhatia S, et al. J Med Chem. 2018 Oct 26. doi: 10.1021/acs.jmedchem.8b01487.

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5)

生物&药学活性

物理化学性质&存储条件

参考文献

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RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5)

生物&药学活性

物理化学性质&存储条件

参考文献

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