RTI-19318-32

Chemical Structure : RTI-19318-32

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货号: PC-25450Not For Human Use, Lab Use Only.

RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%.

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生物&药学活性

RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%.
RTI-19318-32 selectively increases cAMP accumulation in cells overexpressing GPR3, but not GPR6, GPR12, or in HEK293 cells alone.
RTI-19318-32 is able to increase cAMP accumulation in the GPR3 Y188R mutant similar to the wildtype receptor.
RTI-19318-32 attenuates nicotine intake in both male and female mice through GPR3 targeted mechanisms.

物理化学性质&存储条件

分子量	512.16
分子式	C14H7F6IO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dibenziodolium, 3-(trifluoromethoxy)-, 1,1,1-trifluoromethanesulfonate (1:1)

参考文献

1. Elaine A Gay, et al. Bioorg Med Chem Lett. 2023 Oct 1:94:129427.

2. Mogul AS, et al. Neuropsychopharmacology. 2025 Aug 27. doi: 10.1038/s41386-025-02202-3.

RTI-19318-32

生物&药学活性

物理化学性质&存储条件

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RTI-19318-32

生物&药学活性

物理化学性质&存储条件

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