RSV RdRp inhibitor Compound 22

Chemical Structure : RSV RdRp inhibitor Compound 22

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货号: PC-24701Not For Human Use, Lab Use Only.

RSV RdRp inhibitor Compound 22 is a novel non-nucleoside inhibitor of RSV RNA-dependent RNA polymerase (RdRp) with IC50 of 0.27 uM, binds to a novel site in the palm domain of RdRp (SPR KD=0.47 uM).

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100 mg		Get quote

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生物&药学活性

RSV RdRp inhibitor Compound 22 is a novel non-nucleoside inhibitor of RSV RNA-dependent RNA polymerase (RdRp) with IC50 of 0.27 uM, binds to a novel site in the palm domain of RdRp (SPR KD=0.47 uM).
Compound 22 exhibits cellular activity in RSV eGFP phenotypic assay in HeLa cells with EC50 of 2.38 uM.
Compound 22 is similarly efficacious at inhibiting replication of clinically isolated RSV A and B strains as determined by quantitative reverse transcription PCR (RT-qPCR).

物理化学性质&存储条件

分子量	431.72
分子式	C19H16BrClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-bromo-1-methyl-2-oxospiro[indoline-3,4'-piperidin]-1'-yl)-3-chloropicolinonitrile

参考文献

1. Kalin JH, et al. J Virol. 2025 Jun 2:e0017825.