RPI-GLYT2-82

Chemical Structure : RPI-GLYT2-82

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货号: PC-26188Not For Human Use, Lab Use Only.

RPI-GLYT2-82 is a potent, non-competitive, reversible allosteric inhibitor of neuronal glycine transporter GlyT2 with IC50 of 554 nM, selective for GlyT2 over GlyT1.

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生物&药学活性

RPI-GLYT2-82 is a potent, non-competitive, reversible allosteric inhibitor of neuronal glycine transporter GlyT2 with IC50 of 554 nM, selective for GlyT2 over GlyT1.
RPI-GLYT2-82 locks hGlyT2 in an outward-open state.
RPI-GLYT2-82 dissociates from GlyT2 faster than ORG25543, induces analgesia in mouse neuropathic pain models without on-target side-effects or addiction liability.

物理化学性质&存储条件

分子量	407.51
分子式	C24H29N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzoyl-N-((4-(dimethylamino)tetrahydro-2H-pyran-4-yl)methyl)indoline-5-carboxamide

参考文献

1. Cantwell Chater RP, et al. Nat Commun. 2026 Feb 16. doi: 10.1038/s41467-026-69616-5.

RPI-GLYT2-82

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物理化学性质&存储条件

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RPI-GLYT2-82

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