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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-RP-4029
RP-4029

Chemical Structure : RP-4029

CAS No.:

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RP-4029 (RP4029)

货号: PC-26267Not For Human Use, Lab Use Only.

RP-4029 is a potent, selective and covalent inhibitor of DNA polymerase θ (Polθ) with IC50 of 0.013 nM and 6.6 nM for human and mouse Polθ respectively, forms a covalent adduct with Cys2411 of human Polθ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

RP-4029 is a potent, selective and covalent inhibitor of DNA polymerase θ (Polθ) with IC50 of 0.013 nM and 6.6 nM for human and mouse Polθ respectively, forms a covalent adduct with Cys2411 of human Polθ.

物理化学性质&存储条件

分子量 623.57
分子式 C29H23F6N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(2-(2,4-bis(trifluoromethyl)phenyl)-N-phenylacetamido)but-2-yn-1-yl)-2-(vinylsulfonamido)benzamide

参考文献

1. Bubenik M, et al. ACS Med Chem Lett. 2026 Jan 7;17(2):433-440.

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