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首页-小分子抑制剂&激动剂-Others-Other Targets-ROR1 inhibitor 9i
ROR1 inhibitor 9i

Chemical Structure : ROR1 inhibitor 9i

CAS No.:

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ROR1 inhibitor 9i

货号: PC-24711Not For Human Use, Lab Use Only.

ROR1 inhibitor 9i is a potent, selective inhibitor of receptor tyrosine kinase-like orphan receptor ROR1, binds the intracellular kinase domain with KD of 17.2 nM, inhibits ROR1 kinase activity with IC50 of 255 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ROR1 inhibitor 9i is a potent, selective inhibitor of receptor tyrosine kinase-like orphan receptor ROR1, binds the intracellular kinase domain with KD of 17.2 nM, inhibits ROR1 kinase activity with IC50 of 255 nM.

物理化学性质&存储条件

分子量 493.56
分子式 C30H27N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((4'-Acetamido-[1,1'-biphenyl]-3-yl)amino)-N-(2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)-4-methylbenzamide

参考文献

1. Qingquan Zheng, et al. Eur J Med Chem. 2025 Sep 15:294:117755.

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