RO2959

Chemical Structure : RO2959

CAS No.: 1219927-22-6

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货号: PC-27398Not For Human Use, Lab Use Only.

RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with IC50 of 402 nM, inhibits store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with IC50 of 25 nM.

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10 mg	￥3580	In stock
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生物&药学活性

RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with IC50 of 402 nM, inhibits store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with IC50 of 25 nM.
RO2959 is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways.

物理化学性质&存储条件

分子量
分子式	C21H19F2N5OS.xHCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-difluoro-N-(5-(4-methyl-1-(5-methylthiazol-2-yl)-1,2,5,6-tetrahydropyridin-3-yl)pyrazin-2-yl)benzamide hydrochloride

参考文献

1. Chen G, et al. Mol Immunol. 2013 Jul;54(3-4):355-67.

RO2959

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物理化学性质&存储条件

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RO2959

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