RNK06395 | ERK5 degrader | Probechem Biochemicals

Chemical Structure : RNK06395

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RNK06395 (RNK-06395)

货号: PC-28725Not For Human Use, Lab Use Only.

RNK06395 is a potent orally available chaperone-mediated ERK5 degrader (Chaperone-Mediated Protein Degradation, ERK5-CHAMP), degrades ERK5 protein in Huh-7 (Dmax=71.3%, DC50 of 50.98 nM), MOLP-8 (Dmax=84.7%, DC50=24.54 nM).

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生物&药学活性

RNK06395 is a potent orally available chaperone-mediated ERK5 degrader (Chaperone-Mediated Protein Degradation, ERK5-CHAMP), degrades ERK5 protein in Huh-7 (Dmax=71.3%, DC50 of 50.98 nM), MOLP-8 (Dmax=84.7%, DC50=24.54 nM).
RNK06395 inhibited tumor growth after oral administration in a dose-dependent manner in Huh-7 and MOLP-8 xenograft tumor models.

物理化学性质&存储条件

分子量	932.04
分子式	C45H52F3N11O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-((4-(((1r,4r)-4-((5-methyl-11-(methylsulfonyl)-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)cyclohexyl)methyl)piperazin-1-yl)methyl)phenyl)-N-(2,2,2-trifluoroethyl)-4H-1,2,4-triazole-3-carboxamide

参考文献

1. Xiangcai Yang, et al. Cell Commun Signal. 2026 Feb 3;24(1):157.

RNK06395 (RNK-06395)

生物&药学活性

物理化学性质&存储条件

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RNK06395 (RNK-06395)

生物&药学活性

物理化学性质&存储条件

参考文献

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