RN341 | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : RN341

加入收藏

RN341 (RN-341)

货号: PC-24724Not For Human Use, Lab Use Only.

RN341 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 296 nM, binds to the kinase domain of LRRK2.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RN341 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 296 nM, binds to the kinase domain of LRRK2.
RN341 is highly selective against 96 kinases screened in the DSF assay
RN341 display a strong inhibitory effect on LRRK1 kinase activity.
RN341 inhibits LRRK2RCKW-mediated phosphorylation of Rab8a in vitro with IC50 of 110 nM.
RN341 inhibits phosphorylation of LRRK2 substrate Rabs (such as Rab8a) without affecting the phosphorylation of LRRK2 biomarker site S935.
RN341 inhibits phosphorylation of Rab8a by both the wild-type LRRK2 and mutant kinase G2019S LRRK2.
RN341 rescues kinesin motility in the presence of LRRK2 RCKW in in vitro motility assay.

物理化学性质&存储条件

分子量	591.74
分子式	C32H33N9OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(tert-butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(3-(2-(ethylthio)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)urea

参考文献

1. Raig ND, et al. Sci Adv. 2025 Jun 6;11(23):eadt2050.

RN341 (RN-341)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RN341 (RN-341)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.