RN277 | LRRK2 inhibitor | Probechem Biochemicals

Chemical Structure : RN277

加入收藏

RN277 (RN-277)

货号: PC-24723Not For Human Use, Lab Use Only.

RN277 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 135 nM, binds to the kinase domain of LRRK2.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RN277 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 135 nM, binds to the kinase domain of LRRK2.
RN277 display a strong inhibitory effect on LRRK1 kinase activity.
RN277 inhibits LRRK2RCKW-mediated phosphorylation of Rab8a in vitro with IC50 of 70 nM.
RN277 inhibits phosphorylation of LRRK2 substrate Rabs (such as Rab8a) without affecting the phosphorylation of LRRK2 biomarker site S935.
RN277 inhibits phosphorylation of Rab8a by both the wild-type LRRK2 and mutant kinase G2019S LRRK2.
RN277 rescues kinesin motility in the presence of LRRK2 RCKW in in vitro motility assay.

物理化学性质&存储条件

分子量	585.11
分子式	C31H33ClN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(3-(2-chloro-4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)urea

参考文献

1. Raig ND, et al. Sci Adv. 2025 Jun 6;11(23):eadt2050.

RN277 (RN-277)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RN277 (RN-277)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.