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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-RN-1665
RN-1665

Chemical Structure : RN-1665

CAS No.: 1803003-65-7

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RN-1665 (RN1665)

货号: PC-26401Not For Human Use, Lab Use Only.

RN-1665 is a potent, selective and orally active TRPV4 antagonist with IC50 of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4, exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8.

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5 mg ￥2380 In stock
10 mg ￥3880 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RN-1665 is a potent, selective and orally active TRPV4 antagonist with IC50 of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4, exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8.

物理化学性质&存储条件

分子量 513.54
分子式 C20H24F5N3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((4-Isopropylpiperazin-1-yl)sulfonyl)phenyl)-4-(pentafluoro-l6-sulfaneyl)benzamide

参考文献

1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

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