RIPK1 inhibitor 22 |CAS 2095515-38-9 Probechem Biochemicals

Chemical Structure : RIPK1 inhibitor 22

CAS No.: 2095515-38-9

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RIPK1 inhibitor 22 (RIPK1-IN-22)

货号: PC-62633Not For Human Use, Lab Use Only.

RIPK1 inhibitor 22 is a highly potent, orally available, and brain-penetrating RIP1 kinase (RIPK1) inhibitor with pKi of 9.04.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RIPK1 inhibitor 22 (RIPK1-IN-22) is a highly potent, orally available, and brain-penetrating RIP1 kinase (RIPK1) inhibitor with pKi of 9.04.
RIPK1 inhibitor 22 displays excellent specificity for RIP1 kinase over 406 kinases including RIP3 kinase.
RIPK1 inhibitor 22 strongly suppressed necroptotic cell death and phosphorylation of MLKL (pMLKL) in HT-29 cells (nectoptosis; IC50=2.0 nM, pMLKL; IC50 = 1.3 nM) as well as L929 cells (nectoptosis; IC50=15 nM, pMLKL; IC50=2.7 nM).
RIPK1 inhibitor 22 attenuates disease progression in the mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) after oral administration (10 mg/kg, bid).

物理化学性质&存储条件

分子量	461.906
分子式	C24H20ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile

参考文献

1. Yoshikawa M, et al. J Med Chem. 2018 Feb 27. doi: 10.1021/acs.jmedchem.7b01647.

RIPK1 inhibitor 22 (RIPK1-IN-22)

生物&药学活性

物理化学性质&存储条件

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RIPK1 inhibitor 22 (RIPK1-IN-22)

生物&药学活性

物理化学性质&存储条件

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