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首页-小分子抑制剂&激动剂-Autophagy-RH1115
RH1115

Chemical Structure : RH1115

CAS No.: 3080978-62-4

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RH1115 (RH 1115, RH-1115)

货号: PC-21540Not For Human Use, Lab Use Only.

RH1115 is a small molecule activator and inducer of autophagy targeting Lamin A/C and LAMP1, induces changes to LAMP1 vesicle properties and alters lysosome positioning.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RH1115 is a small molecule activator and inducer of autophagy targeting Lamin A/C and LAMP1, induces changes to LAMP1 vesicle properties and alters lysosome positioning.
    RH1115 significantly increase the puncta/cell count in eGFP-LC3 puncta formation assays with EC50 of 46.2 uM.
    RH1115 alters positioning of lysosomes and increases autophagic flux in human iPSC-derived neurons.

    物理化学性质&存储条件

    分子量 356.55
    分子式 C23H36N2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-Benzyl-8-(cyclohexylmethyl)-2,8-diazaspiro[4.5]decan-4-yl)methanol

    参考文献

    1. Ryan S Hippman, et al. ACS Chem Neurosci. 2023 Dec 9. doi: 10.1021/acschemneuro.3c00573.

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