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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-RGT-018
RGT-018

Chemical Structure : RGT-018

CAS No.: 2794934-49-7

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RGT-018 (RGT018)

货号: PC-22804Not For Human Use, Lab Use Only.

RGT-018 (RGT018) is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2.

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5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RGT-018 (RGT018) is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2.

物理化学性质&存储条件

分子量 535.53
分子式 C27H24F3N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-5-(4-((1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-6-morpholino-7-oxo-6,7-dihydropyrido[4,3-d]pyrimidin-8-yl)picolinonitrile

参考文献

1. Xiao F, et al. Mol Cancer Ther. 2024 Aug 1. doi: 10.1158/1535-7163.MCT-24-0049.

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