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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-RETRA
RETRA

Chemical Structure : RETRA

CAS No.: 1036069-26-7

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RETRA

货号: PC-62777Not For Human Use, Lab Use Only.

RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.

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25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
RETRA increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.

物理化学性质&存储条件

分子量 269.333
分子式 C11H11NO3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one

参考文献

1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.

2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.

3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.

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