RDp002

Chemical Structure : RDp002

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货号: PC-24623Not For Human Use, Lab Use Only.

RDp002 is a potent novel small molecule STAT3 inhibitor, interacts with STAT3 SH2 domain with KD of 4.23 uM, inhibits STAT3 phosphorylation of STAT3 at tyrosine 705 and serine 727 residues.

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生物&药学活性

RDp002 is a potent novel small molecule STAT3 inhibitor, interacts with STAT3 SH2 domain with KD of 4.23 uM, inhibits STAT3 phosphorylation of STAT3 at tyrosine 705 and serine 727 residues.
RDp002 (1 uM) markedly impedes the translocation of p-STAT3 (Tyr705) into the nucleus of MM.1S cells.
RDp002 treatment causes a dose-dependent reduction in IL-6-induced STAT3-dependent luciferase reporter activity in 4 T1 and MDA-MB-468 cells.
RDp002 inhibits the phosphorylation of Tyr705 and Ser727, nuclear translocation, transcriptional activity and the expression of downstream target genes regulated by STAT3.
RDp002 (<10 uM) effectively inhibited the proliferation of TNBC and MM cell lines, including MDA-MB-468, MDA-MB-231, 4T1, U266, RPMI-8226 and MM.1S.
RDp002 induced tumour cell death via the lysosomal pathway.
RDp002 (5-10 mg/kg) suppresses tumour growth in subcutaneous xenograft models of MDA-MB-468.

物理化学性质&存储条件

分子量	510.64
分子式	C31H34N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((4-(2-(piperidin-1-yl)ethoxy)benzyl)oxy)naphthalen-1-yl)-3-(pyridin-4-ylmethyl)urea

参考文献

1. Xu MX, et al. Br J Pharmacol. 2025 May 13. doi: 10.1111/bph.70071.

RDp002

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RDp002

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