RANKL inhibitor 34

Chemical Structure : RANKL inhibitor 34

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货号: PC-25328Not For Human Use, Lab Use Only.

RANKL inhibitor 34 is a potent and selective RANKL/RANK inhibitor, displays high affinity for RANKL with SPR Kd of 614 nM, effectively inhibits RANKL-induced osteoclastogenesis and bone resorption.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

RANKL inhibitor 34 is a potent and selective RANKL/RANK inhibitor, displays high affinity for RANKL with SPR Kd of 614 nM, effectively inhibits RANKL-induced osteoclastogenesis and bone resorption.
RANKL inhibitor 34 displays >100-fold selectivity over TNF based on binding affinity.
RANKL inhibitor 34 (5.0 μM) even completely inhibited osteoclast formation.
RANKL inhibitor 34 effectively downregulates the c-fos/NFATc1 signaling in BMMs in a dose-dependent manner.
RANKL inhibitor 34 decreases the mRNA levels and the expression of nuclear receptor NFATc1 and c-fos that controlled the expression of bone resorption enzymes such as TRAP and cathepsin K.

物理化学性质&存储条件

分子量	425.58
分子式	C28H31N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,6-Dimethylphenyl)-3-(1H-indol-3-yl)-2-((3-phenylpropyl)amino)propanamide

参考文献

1. Min Jiang, et al. J Med Chem. 2019 Jun 13;62(11):5370-5381.