RANKL inhibitor 19u

Chemical Structure : RANKL inhibitor 19u

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货号: PC-25333Not For Human Use, Lab Use Only.

RANKL inhibitor 19u is a potent small molecule inhibitor of RANKL-RANK protein interaction with BLI KD of 7.6 uM (RANKL), inhibits RANKL-induced TRAP activity in RAW264.7 cells with IC50 of 0.07 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

RANKL inhibitor 19u is a potent small molecule inhibitor of RANKL-RANK protein interaction with BLI KD of 7.6 uM (RANKL), inhibits RANKL-induced TRAP activity in RAW264.7 cells with IC50 of 0.07 uM.
RANKL inhibitor 19u inhibited RANKL-induced osteoclastogenesis without affecting osteoblast differentiation.
RANKL inhibitor 19u reduced ROS production during osteoclastogenesis and inhibited RANKL-induced bone resorption.
RANKL inhibitor 19u disrupted RANKL-induced osteoclast differentiation by inhibiting MARK/NF-κB signaling pathways and preventing the subsequent induction of the expression of the key osteoclastogenesis regulator NFATc1 and its target genes.
RANKL inhibitor 19u increased bone mass in a dexamethasone-induced osteoporosis model in zebrafish, decreased bone loss in the OVX model.

物理化学性质&存储条件

分子量	621.91
分子式	C40H55N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2R,4aS,6aS,6bS,16aS)-2,4a,6a,6b,9,16a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,16,16a,16b-dodecahydrochryseno[1,2-g]quinoxalin-2-yl)(4-(piperazin-1-yl)piperidin-1-yl)methanone

参考文献

1. Xuefeng Fu, et al. J Med Chem. 2025 Aug 10. doi: 10.1021/acs.jmedchem.5c01380.