RAGE406R

Chemical Structure : RAGE406R

加入收藏

货号: PC-25586Not For Human Use, Lab Use Only.

RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM.
RAGE406R inhibits the ctRAGE activation of DIAPH1. RAGE ligand CML-HSA stimulated migration of murine aortic SMCs in a scratch wound assay with IC50 of 2 nM.
RAGE406R induces significant reduction in CCL2 mRNA expression in primary human macrophages.
RAGE406R (5 mg/kg twice per day by oral gavage) reduced oot pad inflammation score in murine models of delayed type hypersensitivity (DTH) and impaired wound healing in mice with type 2 diabetes (T2D).

物理化学性质&存储条件

分子量	412.49
分子式	C25H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(morpholinomethyl)-2-(4-(5-oxopyrrolidin-2-yl)phenyl)quinoline-7-carbonitrile

参考文献

1. Theophall GG, et al. Cell Chem Biol. 2025 Oct 1:S2451-9456(25)00291-0.

RAGE406R

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RAGE406R

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.