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首页-小分子抑制剂&激动剂-Others-Other Targets-RAGE229
RAGE229

Chemical Structure : RAGE229

CAS No.: 2143072-85-7

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RAGE229 (RAGE-229)

货号: PC-72843Not For Human Use, Lab Use Only.

RAGE229 (RAGE-229) is a specific antagonist of ctRAGE-DIAPH1 interaction, high potently binds to cytoplasmic tail of RAGE (ctRAGE) with KD of 2 nM.

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5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RAGE229 (RAGE-229) is a specific antagonist of ctRAGE-DIAPH1 interaction, high potently binds to cytoplasmic tail of RAGE (ctRAGE) with KD of 2 nM.
RAGE229 directly competes with DIAPH1 for RAGE binding, antagonizes the RAGE-DIAPH1 complex in a dose-dependent manner.
RAGE229 inhibits CML-AGE stimulated cultured smooth muscle cells (SMCs) migration with IC50 of 26 nM, shows no effect on PDGFBB-stimulated SMC migration.
RAGE229 also shows IC50 of 120 nM for inhibition of human SMC migration in primary human aortic SMCs.
RAGE229 assuaged short- and long-term complications of diabetes in both male and female mice, without lowering blood glucose concentrations.
RAGE229 reduced plasma concentrations of TNF-α, IL-6, and CCL2/JE-MCP1 in diabetic mice, in parallel with reduced pathological and functional indices of diabetes-like kidney disease in type 1–like diabetic C57BL/6J mice.

物理化学性质&存储条件

分子量 386.455
分子式 C23H22N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(7-cyano-4-(morpholin-4ylmethyl)quinolin-2-yl)phenyl)acetamide

参考文献

1. Michaele B Manigrasso, et al. Sci Transl Med. 2021 Nov 24;13(621):eabf7084.

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