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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Quisinostat
Quisinostat

Chemical Structure : Quisinostat

CAS No.: 875320-29-9

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Quisinostat (JNJ-26481585, JNJ 26481585)

货号: PC-21412Not For Human Use, Lab Use Only.

Quisinostat (JNJ-26481585) is potent, second-generation histone deacetylase (HDAC) inhibitor with IC50 of 0.11 nM-0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Quisinostat (JNJ-26481585) is potent, second-generation histone deacetylase (HDAC) inhibitor with IC50 of 0.11 nM-0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11.
Quisinostat (JNJ-26481585) induced caspase cascade activation and upregulation of p21, resulting in apoptosis and cell cycle arrest in the myeloma cells at low nanomolar concentrations.
JNJ-26481585 had a potent anti-MM activity that can overcome the stimulatory effect of the BM microenvironment in vivo.
Quisinostat (JNJ-26481585) fully inhibited the growth of C170HM2 colorectal liver metastases, shows broad-spectrum preclinical antitumoral activity.

物理化学性质&存储条件

分子量 394.48
分子式 C21H26N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide

参考文献

1. Deleu S, et al. Leukemia. 2009 Oct;23(10):1894-903.

2. Deleu S, et al. Cancer Res. 2009 Jul 1;69(13):5307-11.

3. Arts J, et al. Clin Cancer Res. 2009 Nov 15;15(22):6841-51.

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