Quinacrine dihydrochloride (Mepacrine dihydrochloride, SN-390) is an antiprotozoal, antirheumatic and intrapleural sclerosing agen, inhibits histamine N-methyltransferase (HNMT),
Quinacrine also strongly induces p53 function, suppresses both basal and inducible activities of NF-kappaB in RCC and other types of cancer cells.
Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth.
