QP6126 | QPCTL inhibitor | Probechem Biochemicals

Chemical Structure : QP6126

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QP6126 (QP-6126)

货号: PC-28153Not For Human Use, Lab Use Only.

QP6126 is a highly potent, orally bioavailable inhibitor of Glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 2.3 nM.

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生物&药学活性

QP6126 is a highly potent, orally bioavailable inhibitor of Glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 2.3 nM.
QP6126 dose-dependently inhibits the formation of pGlu-CD47 in human HEK293T cells and melanoma A375 cells, also significantly and dose-dependently suppresses the binding of recombinant mouse SIRPα protein to CD47 in B16F10 cells.
QP6126 reduces pGlu-CD47, disrupts CD47-SIRPα interaction, and sensitizes melanoma cells to macrophage phagocytosis.
QP6126 exhibited orally active antitumor effects that synergized with anti-PD-1 therapy in B16F10 melanoma mouse model.

物理化学性质&存储条件

分子量	365.43
分子式	C20H16D3FN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-fluoropyridin-3-yl)-2-(4-(4-(methyl-d3)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)benzonitrile

参考文献

1. Xie L, et al. Int Immunopharmacol. 2026 Sep 7;189:117345.

QP6126 (QP-6126)

生物&药学活性

物理化学性质&存储条件

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QP6126 (QP-6126)

生物&药学活性

物理化学性质&存储条件

参考文献

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