QL-X-138

Chemical Structure : QL-X-138

CAS No.: 1469988-63-3

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货号: PC-63076Not For Human Use, Lab Use Only.

QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
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生物&药学活性

QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.
QL-X-138 exhibits covalent binding to BTK and noncovalent binding to MNK.
QL-X-138 enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells.
QL-X-138 arrests cell cycle progression and strongly induces apoptosis.

物理化学性质&存储条件

分子量	421.46
分子式	C25H19N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-Methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide

参考文献

1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81.

2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557.

QL-X-138

生物&药学活性

物理化学性质&存储条件

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QL-X-138

生物&药学活性

物理化学性质&存储条件

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