QC6352 | KDM4 inhibitor | Probechem Biochemicals

Chemical Structure : QC6352

CAS No.: 1851373-36-8

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QC6352 (QC-6352, QC 6352)

货号: PC-61739Not For Human Use, Lab Use Only.

QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively.
QC-6352 displays high selectivity over other KDM family members, with the exception of KDM5B (IC50=750 nM).
QC-6352 shows a promising cellular potency (KYSE-150 EC50=3.5 nM, H3K36 MOA=1.5 nM).
QC-6352 has excellent physical properties and drug-like characteristics, exhibits favorable in vivo efficacy in a breast cancer PDX model and reduces the tumor initiating cell populations which are associated with resistance to chemotherapy treatments.

物理化学性质&存储条件

分子量	387.483
分子式	C24H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(((6-(methyl(phenyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)amino)isonicotinic acid

参考文献

1. Chen YK, et al. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.

QC6352 (QC-6352, QC 6352)

生物&药学活性

物理化学性质&存储条件

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QC6352 (QC-6352, QC 6352)

生物&药学活性

物理化学性质&存储条件

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