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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Q151
Q151

Chemical Structure : Q151

CAS No.: 2226449-95-0

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Q151 (Mtb IMPDH2 inhibitor)

货号: PC-28182Not For Human Use, Lab Use Only.

Q151 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 18 nM, does not inhibit human IMPDH2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Q151 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 18 nM, does not inhibit human IMPDH2.
Q151 shows antitubercular activity against Mtb H37Rv with MIC of 3.1 uM.

物理化学性质&存储条件

分子量 418.40
分子式 C23H16F2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(2-(4-cyanophenyl)benzo[d]oxazol-5-yl)-2-((2,3-difluorophenyl)amino)propanamide

参考文献

1. Chacko S, et al. J Med Chem. 2018 Jun 14;61(11):4739-4756.

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