Pyroxamide

Chemical Structure : Pyroxamide

CAS No.: 382180-17-8

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货号: PC-26230Not For Human Use, Lab Use Only.

Pyroxamide is a potent inhibitor of HDAC with IC50 of 100 nM for HDAC1, causes the accumulation of acetylated core histones in murine erythroleukemia (MEL) cells.

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50 mg	￥1280	In stock
100 mg	￥1980	In stock
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生物&药学活性

Pyroxamide is a potent inhibitor of HDAC with IC50 of 100 nM for HDAC1, causes the accumulation of acetylated core histones in murine erythroleukemia (MEL) cells.
Pyroxamide induces G1 arrest in transformed prostate and bladder cells in culture, induces apoptosis.
Pyroxamide inhibits growth of the CWR22 human prostate xenograft.
Pyroxamide induces growth suppression and cell death in human RMS in vitro.

物理化学性质&存储条件

分子量	265.31
分子式	C13H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-Hydroxy-N8-(pyridin-3-yl)octanediamide

参考文献

1. Kutko MC, et al. Clin Cancer Res. 2003 Nov 15;9(15):5749-55.

2. Butler LM, et al. Clin Cancer Res. 2001 Apr;7(4):962-70.

Pyroxamide

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Pyroxamide

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