Pyripyropene A | ACAT2 inhibitor | Probechem Biochemicals

Chemical Structure : Pyripyropene A

CAS No.: 147444-03-9

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Pyripyropene A (Pyri-A, PPPA)

货号: PC-27358Not For Human Use, Lab Use Only.

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0.25 mg	￥2980	In stock
0.5 mg	￥4880	In stock
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5 mg		Get quote

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生物&药学活性

Pyripyropene A (Pyri-A, PPPA) is a highly potent and selective inhibitor of acyl CoA:cholesterol acyltransferase 2 (ACAT2, Sterol O-acyltransferase 2, SOAT2) with IC50 of 70 nM, >1000-fold selective over SOAT1/ACAT1.
Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia
Pyripyropene A significantly decreased leptin-induced proliferation, migration and invasion of MCF-7 and T47D cells.

物理化学性质&存储条件

分子量	583.63
分子式	C31H37NO10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(Acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate

参考文献

1. Bailly C. Eur J Pharmacol. 2026 Jul 24:179177.

2. Ohshiro T, et al. J Pharmacol Exp Ther. 2015 Nov;355(2):299-307.

3. Ohshiro T, et al. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15.

4. Huang Y, et al. Cell Oncol (Dordr). 2017 Dec;40(6):537-547.

Pyripyropene A (Pyri-A, PPPA)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pyripyropene A (Pyri-A, PPPA)

生物&药学活性

物理化学性质&存储条件

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