Pyrimidyn 7 |CAS:1440126-94-2 Probechem Biochemicals

Chemical Structure : Pyrimidyn 7

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Pyrimidyn 7 (Pyrimidyn7)

货号: PC-62371Not For Human Use, Lab Use Only.

Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin.

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生物&药学活性

Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin.
Pyrimidyn 7 reversibly inhibits CME of both transferrin and EGF in a number of non-neuronal cell lines as well as inhibiting synaptic vesicle endocytosis (SVE) in nerve terminals.
Pyrimidyn 7 blocks clathrin-mediated endocytosis (CME).

物理化学性质&存储条件

分子量	363.59
分子式	C21H41N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine

参考文献

1. McGeachie AB, et al. ACS Chem Biol. 2013 Jul 19;8(7):1507-18.

Pyrimidyn 7 (Pyrimidyn7)

生物&药学活性

物理化学性质&存储条件

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Pyrimidyn 7 (Pyrimidyn7)

生物&药学活性

物理化学性质&存储条件

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