Purvalanol B (NG-95) | CDK inhibitor | Probechem Biochemicals

Chemical Structure : Purvalanol B

CAS No.: 212844-54-7

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Purvalanol B (NG-95, NG95)

货号: PC-45446Not For Human Use, Lab Use Only.

Purvalanol B (NG-95) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.

规格	价格	库存
10 mg	￥880	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

Purvalanol B (NG-95) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.
Purvalanol B shows no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2.

物理化学性质&存储条件

分子量	432.9039
分子式	C20H25ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 40 mg/mL
Chemical Name/SMILES	Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-

参考文献

1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.

2. Chang YT, et al. Chem Biol. 1999 Jun;6(6):361-75.

Purvalanol B (NG-95, NG95)

生物&药学活性

物理化学性质&存储条件

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Purvalanol B (NG-95, NG95)

生物&药学活性

物理化学性质&存储条件

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