Psalmotoxin 1 (PcTx1, Psalmotoxin-1)

Chemical Structure : Psalmotoxin 1

CAS No.: 316808-68-1

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货号: PC-73334Not For Human Use, Lab Use Only.

Psalmotoxin 1 (PcTx1, Psalmotoxin-1) is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker with IC50 of 0.9 nM.

规格	价格	库存
250 ug	￥4980	In stock
500 ug	￥7280	In stock
1 mg		Get quote
5 mg		Get quote

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生物&药学活性

Psalmotoxin 1 (PcTx1, Psalmotoxin-1) is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker with IC50 of 0.9 nM.
Psalmotoxin 1 displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and KV2.1/2.2/4.2/4.3 channels expressed in oocytes at 100 nM.
Psalmotoxin 1 exhibits potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents.

物理化学性质&存储条件

分子量	4689.41
分子式	C200H312N62O57S6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (Modifications: Disulfide bridges: 3-18, 10-23, 17-33)

参考文献

1. Mazzuca M, et al. Nat Neurosci. 2007 Aug;10(8):943-5.