Progerinin | Lamin A-Progerin inhibitor | Probechem Biochemicals

Chemical Structure : Progerinin

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Progerinin (SLC-D011)

货号: PC-24973Not For Human Use, Lab Use Only.

Progerinin (SLC-D011) is a specific, small molecule binding inhibitor of lamin A and progerin, reduces progerin expression and improves aging phenotypes in vitro and in vivo HGPS models.

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生物&药学活性

Progerinin (SLC-D011) is a specific, small molecule binding inhibitor of lamin A and progerin, reduces progerin expression and improves aging phenotypes in vitro and in vivo HGPS models.
Progerinin can extend the life span of LmnaG609G/G609G mouse for about 10 weeks and increase its body weight.
Progerinin can also extend the life span of LmnaG609G/+ mouse for about 14 weeks via oral administration.
Progerinin can induce histological and physiological improvement in LmnaG609G/+ mouse.
Progerinin improves aging-associated alterations in both in vitro and in vivo Hutchinson-Gilford Progeria Syndrome (HGPS) models.

物理化学性质&存储条件

分子量	362.43
分子式	C23H22O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7-(cinnamyloxy)-8,8-dimethyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one

参考文献

1. Kang SM, et al. Cells. 2023 Apr 24;12(9):1232.

2. Kang SM, et al. Commun Biol. 2021 Jan 4;4(1):5.

3. Kang SM, et al. Sci Rep. 2021 Apr 27;11(1):9122.

Progerinin (SLC-D011)

生物&药学活性

物理化学性质&存储条件

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Progerinin (SLC-D011)

生物&药学活性

物理化学性质&存储条件

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