Profilin-1 inhibitor UP-6

Chemical Structure : Profilin-1 inhibitor UP-6

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货号: PC-25256Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Profilin-1 inhibitor UP-6 is a specific small molecule inhibitor of actin-binding protein profilin-1 (Pfn1), inhibits Pfn1-actin interaction and shows potent anti-angiogenic activity in vitro and in vivo.
UP-6 effectively inhibits cord formation of endothelial cells (ECs) with IC50 of 10 uM, has a more potent anti-angiogenic activity than C74.
UP-6 (200 uM) exhibited anti-angiogenesis in C57/Bl6 mice, significantly reduced EC infiltration into the plugs.

物理化学性质&存储条件

分子量	348.37
分子式	C18H19F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-((4-(trifluoromethyl)phenyl)methylene)bis(3,5-dimethyl-1H-pyrazole)

参考文献

1. Gau D, et al. bioRxiv [Preprint]. 2025 Jul 21:2025.07.18.665115.