Pomalidomide (CC4047) | IKZF1 degrader | Probechem Biochemicals

Chemical Structure : Pomalidomide

CAS No.: 19171-19-8

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Pomalidomide (CC-4047, CC4047)

货号: PC-42764Not For Human Use, Lab Use Only.

Pomalidomide (CC4047) is a potent IKZF1 degrader with DC50 of 6 nM and Dmax=86%, has no effect on IKZF2 protein levels up to 50 μM.

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25 mg	￥580	In stock
100 mg	￥980	In stock
500 mg	￥1380	In stock
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生物&药学活性

Pomalidomide (CC4047) is a potent IKZF1 degrader with DC50 of 6 nM and Dmax=86%, has no effect on IKZF2 protein levels up to 50 μM.

Pomalidomide is potent inhibitor of TNF-α production, inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs, upregulates interferon gamma, IL-2 and IL-10.

物理化学性质&存储条件

分子量	273.2441
分子式	C13H11N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-

参考文献

1. Muller GW, et al. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30.

2. Payvandi F, et al. Cell Immunol. 2004 Aug;230(2):81-8.

3. Galustian C, et al. Cancer Immunol Immunother. 2009 Jul;58(7):1033-45.

Pomalidomide (CC-4047, CC4047)

生物&药学活性

物理化学性质&存储条件

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Pomalidomide (CC-4047, CC4047)

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物理化学性质&存储条件

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