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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-PolQi2
PolQi2

Chemical Structure : PolQi2

CAS No.: 2565638-16-4

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PolQi2

货号: PC-24608Not For Human Use, Lab Use Only.

PolQi2 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 0.238 uM (MH-mediated deletion), inhibits the helicase activity of Polϴ.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

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PolQi2 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 0.238 uM (MH-mediated deletion), inhibits the helicase activity of Polϴ.

物理化学性质&存储条件

分子量 453.90
分子式 C21H16ClN5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-((5-Chloropyridin-2-yl)methoxy)-1,3,4-thiadiazol-2-yl)-3-(2-methoxyphenyl)isonicotinamide

参考文献

1. Wimberger, S. et al. Nat Commun. 2023 Aug 14;14(1):4761.

2. Patent WO202/0243459.

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