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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-PolQi1
PolQi1

Chemical Structure : PolQi1

CAS No.: 2607139-80-8

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PolQi1

货号: PC-24607Not For Human Use, Lab Use Only.

PolQi1 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 2.48 uM (MH-mediated deletion), targets the polymerase domain of Polϴ.

规格 价格 库存 数量
2 mg ￥1580 In stock
5 mg ￥2880 In stock
10 mg ￥4580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PolQi1 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 2.48 uM (MH-mediated deletion), targets the polymerase domain of Polϴ.

物理化学性质&存储条件

分子量 448.78
分子式 C18H14ClF5N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)-

参考文献

1. Wimberger, S. et al. Nat Commun. 2023 Aug 14;14(1):4761.

2. Patent WO2021/028643.

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