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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGFβ-Smad-Pirfenidone
Pirfenidone

Chemical Structure : Pirfenidone

CAS No.: 53179-13-8

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Pirfenidone (AMR69)

货号: PC-24495Not For Human Use, Lab Use Only.

Pirfenidone (AMR69) is an antifibrotic agent and TGF-β inhibitor, attenuates CCL2 and CCL12 production in fibrocyte cells, shows growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines.

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100 mg ￥480 In stock
500 mg ￥880 In stock
1 g ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pirfenidone (AMR69) is an antifibrotic agent and TGF-β inhibitor, attenuates CCL2 and CCL12 production in fibrocyte cells, shows growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines.

物理化学性质&存储条件

分子量 185.23
分子式 C12H11NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Methyl-1-phenylpyridin-2(1H)-one

参考文献

1. Taniyama M, et al. Eur J Clin Pharmacol. 1997;52(1):77-8.

2. Lee BS, et al. J Clin Endocrinol Metab. 1998 Jan;83(1):219-23.

3. Silva TA, et al. Int J Mol Sci. 2024 Jul 3;25(13):7302.

4. Burghardt I, et al. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7.

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