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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -Pinokalant
Pinokalant

Chemical Structure : Pinokalant

CAS No.: 149759-26-2

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Pinokalant (LOE908, LOE-908)

货号: PC-25775Not For Human Use, Lab Use Only.

Pinokalant (LOE908, LOE-908) is an inhibitor of receptor-operated Ca(2+) channels (ROCCs) and non-selective cation channel inhibitor, inhibits store-operated Ca2+ entry (SOCE) induced by direct depletion of Ca2+ stores with 100 nM thapsigargin or 100 nM ionomycin with EC50 of 2 uM and 4 uM, respectively.

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10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

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Pinokalant (LOE908, LOE-908) is an inhibitor of receptor-operated Ca(2+) channels (ROCCs) and non-selective cation channel inhibitor, inhibits store-operated Ca2+ entry (SOCE) induced by direct depletion of Ca2+ stores with 100 nM thapsigargin or 100 nM ionomycin with EC50 of 2 uM and 4 uM, respectively.
Pinokalant (LOE908, LOE-908) does not affect thapsigargin- or ionomycin-induced Ca2+ release from intracellular stores.
Pinokalant (LOE908, LOE-908) reversibly suppressed thapsigargin- as well as ionomycin-induced whole-cell membrane currents.

物理化学性质&存储条件

分子量 712.84
分子式 C41H48N2O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)-2-phenyl-N,N-bis(2,3,4-trimethoxyphenethyl)acetamide

参考文献

1. Krautwurst D, et al. Mol Pharmacol. 1993 May;43(5):655-9.

2. Krautwurst D, et al. Naunyn Schmiedebergs Arch Pharmacol. 1994 Mar;349(3):301-7.

3. Encabo A, et al. Br J Pharmacol. 1996 Oct;119(4):702-6.

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