Pimodivir (VX-787, JNJ872, JNJ 63623872)

Chemical Structure : Pimodivir

CAS No.: 1629869-44-8

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货号: PC-42998Not For Human Use, Lab Use Only.

Pimodivir (VX-787, JNJ872, JNJ 63623872) is a first-in-class, orally bioavailable inhibitor of influenza virus polymerase PB2 subunit with Kd of <3 nM, CPE EC50 of 2 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Pimodivir (VX-787, JNJ872, JNJ 63623872) is a first-in-class, orally bioavailable inhibitor of influenza virus polymerase PB2 subunit with Kd of <3 nM, CPE EC50 of 2 nM.
Pimodivir (VX-787, JNJ872, JNJ 63623872) shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains with mean CPE EC50 of <2 nM.
Pimodivir (VX-787) is highly efficacious in both prophylaxis and treatment models of mouse influenza and is superior to the neuraminidase inhibitor Oseltamivir.

物理化学性质&存储条件

分子量	399.394
分子式	C20H19F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 12.5 mg/mL
Chemical Name/SMILES	Bicyclo[2.2.2]octane-2-carboxylic acid, 3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-, (2S,3S)-

参考文献

1. Clark MP, et al. J Med Chem. 2014 Aug 14;57(15):6668-78.

2. Byrn RA, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82.

3. Ma X, et al. Sci Rep. 2017 Aug 24;7(1):9385.