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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-Phenformin
Phenformin

Chemical Structure : Phenformin

CAS No.: 114-86-3

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Phenformin (Phenethylbiguanide)

货号: PC-26811Not For Human Use, Lab Use Only.

Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent that inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent that inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy.

物理化学性质&存储条件

分子量 205.27
分子式 C10H15N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Phenethylbiguanide

参考文献

1. García Rubiño ME, et al. Int J Mol Sci. 2019;20(13):3316. Published 2019 Jul 5.

2. Hu S, et al. Mol Med Rep. 2018;17(4):6028-6032.

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