Perifosine (KRX-0401, D21266) | Akt inhibitor | Probechem Biochemicals

Chemical Structure : Perifosine

CAS No.: 157716-52-4

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Perifosine (KRX-0401, NSC639966, D-21266, KRX0401, D21266)

货号: PC-45903Not For Human Use, Lab Use Only.

Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway.
Perifosine enhances apoptosis and inhibits the growth of xenografts in nude mice combined with a lysosomal inhibitor.
Perifosine displays significant antiproliferative activity in vitro and in vivo in several human tumor model

物理化学性质&存储条件

分子量	461.6584
分子式	C25H52NO4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt

参考文献

1. Kondapaka SB, et al. Mol Cancer Ther. 2003 Nov;2(11):1093-103.

2. Patel V, et al. Cancer Res. 2002 Mar 1;62(5):1401-9.

3. Becher OJ, et al. Cancer Res. 2010 Mar 15;70(6):2548-57.

Perifosine (KRX-0401, NSC639966, D-21266, KRX0401, D21266)

生物&药学活性

物理化学性质&存储条件

参考文献

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Perifosine (KRX-0401, NSC639966, D-21266, KRX0401, D21266)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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