PYZD-4409 |CAS:423148-78-1 Probechem Biochemicals

Chemical Structure : PYZD-4409

CAS No.: 423148-78-1

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PYZD-4409 (PYZD4409;PYZD 4409)

货号: PC-43475Not For Human Use, Lab Use Only.

PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM.

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10 mg	￥2480	In stock
25 mg	￥3980	In stock
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生物&药学活性

PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM.
PYZD-4409 inhibits the ATP-dependent activation of ubiquitin and subsequent transfer of the activated ubiquitin from the E1 to the common human E2 enzyme UBE2E2.
PYZD-4409 blockes the E1-dependent conjugation of ubiquitin to the E2 enzyme cdc3, induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells.
PYZD-4409 decreases tumor weight and volume without untoward toxicity in vivo.

物理化学性质&存储条件

分子量	351.67
分子式	C14H7ClFN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-

参考文献

1. Xu GW, et al. Blood. 2010 Mar 18;115(11):2251-9.

PYZD-4409 (PYZD4409;PYZD 4409)

生物&药学活性

物理化学性质&存储条件

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PYZD-4409 (PYZD4409;PYZD 4409)

生物&药学活性

物理化学性质&存储条件

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