PYCR1-IN-1 | PYCR1 inhibitor | Probechem Biochemicals

Chemical Structure : PYCR1-IN-1

CAS No.: 709-85-3

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PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1)

货号: PC-25725Not For Human Use, Lab Use Only.

PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1) is a small molecule pyrroline-5-carboxylate reductase 1 (PYCR1) inhihibitor with IC50 of 8.8 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1) is a small molecule pyrroline-5-carboxylate reductase 1 (PYCR1) inhihibitor with IC50 of 8.8 uM.
PYCR1-IN-1 (ProPI-1) prevents the formation of proline in human breast cancer cell line (SUM-159-PT) with IC50 of 1 uM, with no effect on the other amino acid levels.
PYCR1-IN-1 (ProPI-1) is approximately 20 times more potent than pargyline
PYCR1-IN-1 (ProPI-1) can control cell proliferation in two different breast cancer cell types MDA-MB-231 and SUM-159-PT, both cells have relatively high PYCR1 levels, and depend on PYCR1 activity for proliferation and tumor formation.

物理化学性质&存储条件

分子量	238.13
分子式	C11H12BrN
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Bromobenzyl)-N-methylprop-2-yn-1-amine

参考文献

1. Kirsty Milne, et al. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2626-2631.

2. Shin JH, et al. Exp Mol Med. 2025 Nov 18. doi: 10.1038/s12276-025-01577-z.

PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1)

生物&药学活性

物理化学性质&存储条件

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PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1)

生物&药学活性

物理化学性质&存储条件

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