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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-PX-866
PX-866

Chemical Structure : PX-866

CAS No.: 502632-66-8

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PX-866 (Sonolisib, PX866)

货号: PC-27224Not For Human Use, Lab Use Only.

Sonolisib (PX-866) is a Wortmannin analogue and an oral, irreversible, and pan-isoform PI3K inhibitor with IC50 of 0.1 nM, 1.0 nM and 2.9 nM for p110α, p120γ and p110δ.

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sonolisib (PX-866) is a Wortmannin analogue and an oral, irreversible, and pan-isoform PI3K inhibitor with IC50 of 0.1 nM, 1.0 nM and 2.9 nM for p110α, p120γ and p110δ.
Sonolisib (PX-866) inhibits PI3-kinase signaling measured by phospho-Ser473-Akt levels in HT-29 colon cancer cells with IC50 of 20 nM.
Sonolisib (PX-866) at 10 mg/kg inhibited phospho-Ser473-Akt in HT-29 colon tumor xenografts up to 80% with recovery taking >48 hours after p.o. administration but more rapidly after i.v. or i.p. administration.
Sonolisib (PX-866) exhibited in vivo antitumor activity against s.c. OvCar-3 human ovarian cancer and A-549 human lung cancer xenografts in immunodeficient mice.

物理化学性质&存储条件

分子量 525.60
分子式 C29H35NO8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione, 5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-, (1E,4S,4aR,5R,6aS,9aR)-

参考文献

1. Ihle NT, et al. Mol Cancer Ther. 2004 Jul;3(7):763-72.

2. Ihle NT, et al. Mol Cancer Ther. 2005 Sep;4(9):1349-57.

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